Comiket 72 (August 2007) was peak Naruto Shippuden era. Tsunade had already shown her Creation Rebirth during the Orochimaru invasion arc, and fans were obsessed with her combination of strength, age-defying transformation, and medical genius.
To find the specific chapter and understand the context: c72 naruhodou naruhodo tsunade no inchiryou naruto link
The patients, it turned out, were unwitting test subjects. The injuries were a result of an unforeseen side effect, causing their bodies to react to the latent, invisible chakra. The C72 coordinate corresponded to a specific location where the experiment had been conducted. Comiket 72 (August 2007) was peak Naruto Shippuden era
: Both belong to the Senju/Uzumaki lineage, which are distant cousins. Emotional Bond it turned out