Wilms Tumor Ppt New ((install))

Approximately 10–15% of cases are associated with a predisposition syndrome. Genetic Marker W ilms, A niridia, G enitourinary anomalies, R etardation 11p13 deletion (WT1) Denys-Drash Nephropathy, Wilms, ambiguous genitalia WT1 mutation Beckwith-Wiedemann Overgrowth, macroglossia, omphalocele 11p15 (WT2/IGF2) Perlman Fetal gigantism, nephroblastomatosis 🔬 Pathology & Staging Histology Types

The staging of Wilms tumor is based on the extent of the disease. The most commonly used staging system is the National Wilms Tumor Study Group (NWTSG) staging system, which includes: wilms tumor ppt new

Wilms tumor management is a testament to the power of collaborative clinical trials. Current efforts focus on "de-escalation"—reducing treatment intensity for low-risk patients to minimize late effects, while intensifying therapy for those with unfavorable molecular markers. Approximately 10–15% of cases are associated with a

The cure rate is excellent, but survivors require lifelong monitoring for: Monitoring for chronic kidney disease. Cardiotoxicity: If Doxorubicin or chest radiation was used. | Stage | COG (Primary Nephrectomy) | SIOP

| Stage | COG (Primary Nephrectomy) | SIOP (Pre-op Chemo) | |-------|----------------------------|----------------------| | I | Tumor limited to kidney, completely excised | >2/3 necrosis post-chemo | | II | Extracapsular extension but completely excised | ≤2/3 necrosis | | III | Residual tumor (lymph nodes, positive margins, spillage) | Incomplete resection | | IV | Hematogenous metastases (lung, liver, brain) | Same | | V | Bilateral renal involvement at diagnosis | Same |

: Characterized by early-onset renal failure and pseudohermaphroditism.